Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42
Y.-C. Tseng, S. G. Liva, A. M. Dauki, M. Sovic, S. E. Henderson, Y.-C. Kuo, J. A. Benedict, S. K. Kulp, M. Campbell, T. Bekaii-Saab, M. A. Phelps, C.-S. Chen, C. C. Coss
This study combines a SARM and HDAC inhibitor to improve anti-cachectic efficacy in a mouse model of cancer cachexia, showing significant improvements in bodyweight and muscle mass.
bioRxiv · Oct 5, 2018 · PreprintCancer Biology