Cryptic β-lactamase evolution is driven by low β-lactam concentrations
C. Frohlich, J. A. Gama, K. Harms, V. H. A. Hirvonen, B. A. Lund, M. W. van der Kamp, P. J. Johnsen, O. Samuelsen, H.-K. S. Leiros
The paper shows that low β-lactam concentrations drive cryptic evolution of β-lactamases through fitness benefits in competition experiments, not increased resistance.
bioRxiv · Dec 1, 2020Evolutionary Biology