Author

C. Frohlich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

P. J. Johnsen· 3 shared H.-K. S. Leiros· 2 shared M. W. van der Kamp· 2 shared A. J. Mulholland· 1 shared A. S. B. Haukefer· 1 shared B. A. Lund· 1 shared F. Frohlich· 1 shared H. A. Bunzel· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersEvolutionary Biology

P. J. Johnsen

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Author profile →

4 papers

Recent·Most cited

The Biofilm Lifestyle Shapes the Evolution of β-Lactamases

O. M. Lorentzen, A. S. B. Haukefer, P. J. Johnsen, C. Frohlich

This study shows that biofilm lifestyle selects for mutations in β-lactamases that reduce biofilm inhibition while maintaining antibiotic resistance.

bioRxiv · Oct 2, 2023Microbiology

Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

C. Frohlich, H. A. Bunzel, K. Buda, A. J. Mulholland, M. W. van der Kamp, P. J. Johnsen, H.-K. S. Leiros, N. Tokuriki

This study shows that epistasis in enzyme evolution arises from shifting the rate-limiting step in the catalytic cycle, leading to substantial activity enhancements through synergistic mutations.

bioRxiv · Jun 29, 2023Evolutionary Biology

Cryptic β-lactamase evolution is driven by low β-lactam concentrations

C. Frohlich, J. A. Gama, K. Harms, V. H. A. Hirvonen, B. A. Lund, M. W. van der Kamp, P. J. Johnsen, O. Samuelsen, H.-K. S. Leiros

The paper shows that low β-lactam concentrations drive cryptic evolution of β-lactamases through fitness benefits in competition experiments, not increased resistance.

bioRxiv · Dec 1, 2020Evolutionary Biology

Exploring the Relationship between Geomagnetic Activity and Human Heart Rate Variability

M. Mattoni, S. Ahn, C. Frohlich, F. Frohlich

This study investigates the relationship between geomagnetic activity and heart rate variability (HRV) in 20 healthy participants, finding weak correlations that may be due to autocorrelation and lack of multiple comparison correction.

bioRxiv · Jun 26, 2019Physiology