Author

H.-K. S. Leiros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Frohlich· 2 shared M. W. van der Kamp· 2 shared P. J. Johnsen· 2 shared A. J. Mulholland· 1 shared B. A. Lund· 1 shared H. A. Bunzel· 1 shared J. A. Gama· 1 shared K. Buda· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

C. Frohlich

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Evolutionary BiologybioRxivJun 29, 2023

Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

C. Frohlich, H. A. Bunzel, K. Buda…·N. Tokuriki

This study shows that epistasis in enzyme evolution arises from shifting the rate-limiting step in the catalytic cycle, leading to substantial activity enhancements through synergistic mutations.

DOI 10.1038/s41929-024-01117-4

experimental assay

𝕏 PostBluesky

Evolutionary BiologybioRxivDec 1, 2020

Cryptic β-lactamase evolution is driven by low β-lactam concentrations

C. Frohlich, J. A. Gama, K. Harms…·H.-K. S. Leiros

The paper shows that low β-lactam concentrations drive cryptic evolution of β-lactamases through fitness benefits in competition experiments, not increased resistance.

DOI 10.1128/msphere.00108-21

E. coliproteomics

𝕏 PostBluesky