Author

B. Mostofian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Approach:deep learning· 3 Organism:human· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Assay:imaging· 2

Frequent Co-Authors

D. M. Zuckerman· 6 shared B. L. Patton· 2 shared M. W. Sung· 2 shared S.-L. Shyng· 2 shared X. Nan· 2 shared Y. H. Chang· 2 shared A. Agrawal· 1 shared A. Dickson· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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6 shared papersBiophysics

D. M. Zuckerman

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Author profile →

7 papers

Recent·Most cited

Continuum dynamics and statistical correction of compositional heterogeneity in multivalent IDP oligomers resolved by single-particle EM

B. Mostofian, R. McFarland, A. Estelle, J. Howe, E. Barbar, D. M. Zuckerman, S. L. Reichow

This paper develops a pipeline to analyze multivalent IDP oligomers using single-particle EM, correcting compositional heterogeneity and revealing new insights into their structure and function.

Journal of Molecular Biology · May 1, 2022Peer-reviewedBiophysics

Ligand-mediated structural dynamics of a mammalian pancreatic KATP channel

M. W. Sung, C. M. Driggers, B. Mostofian, J. D. Russo, B. L. Patton, D. M. Zuckerman, S.-L. Shyng

The paper investigates how ligands affect the structural dynamics of pancreatic KATP channels using cryo-EM and molecular dynamics simulations.

bioRxiv · Mar 2, 2022Biochemistry

Atomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange

T. Dixon, D. MacPherson, B. Mostofian, T. Dauzhenka, S. Lotz, D. McGee, S. Shechter, U. Shrestha, R. Wiewiora, Z. A. McDargh, F. Pei, R. Pal, J. V. Ribeiro, T. Wilkerson, V. Sachdeva, , J. A. Izaguirre

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

bioRxiv · Sep 26, 2021 · PreprintBiophysics

Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides

M. W. Sung, Z. Yang, B. L. Patton, B. Mostofian, J. Russo, D. M. Zuckerman, S.-L. Shyng

The paper determines cryoEM structures of vascular KATP channels bound to Mg-nucleotides and reveals a conformational pathway for activation.

bioRxiv · May 15, 2021Biochemistry

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

W. Y. Lam, Y. Wang, B. Mostofian, D. Jorgens, S. Kwon, K. Chin, M. Carpenter, T. Jacob, K. Heiser, A. Agrawal, J. Wang, X. Nan, Y. H. Chang, D. M. Zuckerman, J. Gray, , T. Q. Vu

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

bioRxiv · Jun 2, 2019 · PreprintCancer Biology

Computational estimation of ms-sec atomistic folding times

U. Adhikari, B. Mostofian, J. Copperman, A. Petersen, D. M. Zuckerman

The paper estimates atomistic protein folding times using weighted ensemble simulations on GPUs, showing reduced computational cost compared to conventional MD simulations.

bioRxiv · Mar 15, 2019Biophysics

High-throughput single-particle tracking reveals nested membrane nanodomain organization that dictates Ras diffusion and trafficking

Y. Lee, C. Phelps, T. Huang, B. Mostofian, L. Wu, Y. Zhang, Y. H. Chang, P. J. S. Stork, J. W. Gray, D. M. Zuckerman, X. Nan

This study uses single-particle tracking to show that KRas diffusion and trafficking are regulated by nested membrane nanodomains in U2OS cells.

bioRxiv · Mar 5, 2019Biophysics