Author

J. A. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bode· 2 shared R. An· 2 shared U. A. Gurkan· 2 shared U. Goreke· 2 shared Y. Man· 2 shared C. Chen· 1 shared C. L. Wirth· 1 shared E. Kucukal· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

A. Bode

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2 papers

Recent·Most cited

Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin

U. Goreke, S. Iram, G. Singh, S. Dominguez-Medina, Y. Man, A. Bode, R. An, J. A. Little, C. L. Wirth, M. Hinczewski, U. A. Gurkan

This paper investigates catch bonding in sickle cell disease by measuring RBC adhesion dynamics to laminin under shear flow, revealing patient-specific variations in bond strength and clinical relevance.

Biophysical Journal · Jun 1, 2023Peer-reviewedBiophysics

Sickle red blood cell derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor

R. An, Y. Man, K. Cheng, T. Zhang, C. Chen, E. Kucukal, W. Wulftange, U. Goreke, A. Bode, L. Nayak, G. M. Vercellotti, J. D. Belcher, J. A. Little, U. A. Gurkan

This study shows that sickle RBC-derived extracellular vesicles activate endothelial cells and enhance RBC adhesion via von Willebrand factor, with implications for SCD treatment.

bioRxiv · May 25, 2022Cell Biology