Author

U. Goreke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:imaging· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

U. A. Gurkan· 4 shared M. Hinczewski· 3 shared R. An· 3 shared Y. Man· 3 shared A. Bode· 2 shared G. Singh· 2 shared J. A. Little· 2 shared S. Iram· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiophysics

U. A. Gurkan

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Author profile →

4 papers

Recent·Most cited

Motion Blur Microscopy

U. Goreke, A. Gonzales, B. Shipley, M. Tincher, O. Sharma, W. Wulftange, Y. Man, R. An, M. Hinczewski, U. A. Gurkan

This paper introduces motion blur microscopy to image cell adhesion in whole blood flow without dilution, enabling analysis of adhesion dynamics in physiological conditions.

bioRxiv · Oct 8, 2023 · PreprintBiophysics

Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin

U. Goreke, S. Iram, G. Singh, S. Dominguez-Medina, Y. Man, A. Bode, R. An, J. A. Little, C. L. Wirth, M. Hinczewski, U. A. Gurkan

This paper investigates catch bonding in sickle cell disease by measuring RBC adhesion dynamics to laminin under shear flow, revealing patient-specific variations in bond strength and clinical relevance.

Biophysical Journal · Jun 1, 2023Peer-reviewedBiophysics

Sickle red blood cell derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor

R. An, Y. Man, K. Cheng, T. Zhang, C. Chen, E. Kucukal, W. Wulftange, U. Goreke, A. Bode, L. Nayak, G. M. Vercellotti, J. D. Belcher, J. A. Little, U. A. Gurkan

This study shows that sickle RBC-derived extracellular vesicles activate endothelial cells and enhance RBC adhesion via von Willebrand factor, with implications for SCD treatment.

bioRxiv · May 25, 2022Cell Biology

Integrating deep learning with microfluidics for biophysical classification of sickle red blood cells

N. Praljak, S. Iram, U. Goreke, G. Singh, A. Hill, U. A. Gurkan, M. Hinczewski

This paper develops a deep learning workflow for automated classification of sickle red blood cells using microfluidic images, achieving accuracy comparable to human experts with significantly faster analysis.

bioRxiv · Jul 1, 2020 · PreprintBiophysics