Author

J. D. Belcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 1

Frequent Co-Authors

G. M. Vercellotti· 2 shared A. Bode· 1 shared A. N. Brown· 1 shared B. A. Rohrman· 1 shared B. E. Bolivar· 1 shared C. Chen· 1 shared C. I. Charendoff· 1 shared E. Kucukal· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

G. M. Vercellotti

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2 papers

Recent·Most cited

Sickle red blood cell derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor

R. An, Y. Man, K. Cheng, T. Zhang, C. Chen, E. Kucukal, W. Wulftange, U. Goreke, A. Bode, L. Nayak, G. M. Vercellotti, J. D. Belcher, J. A. Little, U. A. Gurkan

This study shows that sickle RBC-derived extracellular vesicles activate endothelial cells and enhance RBC adhesion via von Willebrand factor, with implications for SCD treatment.

bioRxiv · May 25, 2022Cell Biology

Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death

B. E. Bolivar, A. N. Brown, B. A. Rohrman, C. I. Charendoff, V. Yazdani, J. D. Belcher, G. M. Vercellotti, J. M. Flanagan, L. Bouchier-Hayes

This paper identifies extracellular heme as a DAMP that activates caspase-1, caspase-4, and caspase-5, leading to IL-1β release and cell death in macrophages, with caspase-4 playing a primary role in cell death.

bioRxiv · Feb 28, 2020Immunology