J. A. MacDonald

Cooperative involvement of zipper-interacting protein kinase (ZIPK) and the dual-specificity cell division cycle 14A phosphatase (CDC14A) in vascular smooth muscle cell migration

This study identifies ZIPK and CDC14A as regulators of FAK phosphorylation and VSMC migration through their interaction and signaling pathway.

Sex dimorphism in the aged metabolic phenotype of smoothelin-like 1 (SMTNL1) deficient mice

This study examines the sex-specific effects of SMTNL1 deletion on metabolic phenotype in aged mice, finding increased adiposity and altered energy metabolism in females.

Structural Insights into the ATP-dependent Activation of NOD-like Receptor with Pyrin 3 (NLRP3) Protein by Molecular Dynamics Simulation

This study uses molecular dynamics simulations to show that ATP binding induces conformational changes in NLRP3, while ADP binding stabilizes its structure.

Death-associated protein kinase 3 (DAPK3) regulates the myogenic reactivity of cerebral arterioles

This study shows DAPK3 regulates actin cytoskeleton in cerebral arterioles, not Ca2+ sensitization, and its inhibition affects myogenic reactivity in rat and human vessels.

Death-associated protein kinase 3 (DAPK3) contributes to intestinal epithelial wound healing and the resolution of experimental colitis in mice

This study shows that DAPK3 inhibition impairs intestinal epithelial wound healing and colitis resolution in mice by affecting YAP signaling.

Simultaneous Binding of the N- and C-terminal Cytoplasmic Domains of Aquaporin 4 to Calmodulin May Contribute to Vesicular Trafficking

This study investigates the CaM-binding properties of AQP4's N- and C-terminal domains, revealing a unique binding mode that may regulate vesicular trafficking.

Enhanced diastolic dysfunction but preserved systolic function after acute pressure overload in the absence of smoothelin-like 1 protein

This study shows that SMTNL1 knockout mice exhibit enhanced diastolic dysfunction but preserved systolic function after acute pressure overload, resembling HFpEF pathophysiology.