Author

J. A. Manuel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. P. Smith· 4 shared B. A. Berryhill· 4 shared B. R. Levin· 4 shared F. Baquero· 4 shared T. Gil-Gil· 4 shared A. S. Ismail· 1 shared B. R. R. Levin· 1 shared D. A. Goldberg· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

A. P. Smith

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus

A. S. Ismail, B. A. Berryhill, T. Gil-Gil, J. A. Manuel, A. P. Smith, F. Baquero, B. R. Levin

This study examines how sub-inhibitory antibiotic concentrations affect mutation rates and persistence in Staphylococcus aureus, showing increased mutation rates and reduced persistence.

bioRxiv · Apr 1, 2024 · PreprintMicrobiology

The Evolution of Heteroresistance via Small Colony Variants in Escherichia coli Following Long Term Exposure to Bacteriostatic Antibiotics

T. Gil-Gil, B. A. Berryhill, J. A. Manuel, A. P. Smith, F. Baquero, B. R. Levin

This study shows that long-term exposure to bacteriostatic antibiotics in E. coli leads to the emergence of small colony variants (SCVs) that confer heteroresistance, which reverts upon antibiotic removal.

bioRxiv · Oct 30, 2023 · PreprintMicrobiology

Theoretical Considerations and Empirical Predictions of the Pharmaco- and Population Dynamics of Heteroresistance

B. R. R. Levin, B. A. Berryhill, T. Gil-Gil, J. A. Manuel, A. P. Smith, J. E. Choby, D. I. Andersson, D. S. Weiss, F. Baquero

This paper develops two mathematical models of heteroresistance to explore how resistance ascends and reverts during antibiotic treatment, showing that current identification methods are insufficient.

bioRxiv · Sep 21, 2023Microbiology

The contribution of abortive infection to preventing populations of Lactococcus lactis from succumbing to infections with bacteriophage

E. Rodriguez-Roman, J. A. Manuel, D. A. Goldberg, B. R. Levin

This study investigates how abortive infection (Abi) in Lactococcus lactis limits phage proliferation and prevents population extinction, showing Abi is effective but not sufficient for complete protection.

bioRxiv · Jun 23, 2023 · PreprintMicrobiology

What's the matter with MICs: The contribution of nutrients and limiting resources to the pharmacodynamics of antibiotics and bacteria

B. A. Berryhill, T. Gil-Gil, J. A. Manuel, A. P. Smith, E. Margollis, F. Baquero, B. R. Levin

This study investigates how nutrient conditions affect antibiotic pharmacodynamics by comparing MICs and bacterial growth in rich and minimal media with E. coli and eight antibiotics.

bioRxiv · Sep 30, 2022 · PreprintMicrobiology