Cancer BiologybioRxiv
Targeting the PI3K/AKT pathway overcomes enzalutamide resistance by inhibiting induction of the glucocorticoid receptor
R. M. Adelaiye-Ogala, B. Gryder, Y. T. M. Nguyen…·D. J. VanderWeele
This study shows that inhibiting the PI3K/AKT pathway blocks GR induction and overcomes enzalutamide resistance in prostate cancer by remodeling chromatin and enhancing AR activity.
DOI 10.1158/1535-7163.mct-19-0936