Targeting the PI3K/AKT pathway overcomes enzalutamide resistance by inhibiting induction of the glucocorticoid receptor
R. M. Adelaiye-Ogala, B. Gryder, Y. T. M. Nguyen, A. N. Alilin, A. Grayson, K. H. Jansson, M. L. Beshiri, S. Agarwal, B. Capaldo, J. A. Rodriguez-Nieves, K. Kelly, D. J. VanderWeele
This study shows that inhibiting the PI3K/AKT pathway blocks GR induction and overcomes enzalutamide resistance in prostate cancer by remodeling chromatin and enhancing AR activity.
bioRxiv · Oct 1, 2019Cancer Biology