J. A. Ronald

Delivery of human adipose-derived stromal cells within in situ forming chitosan/PEG-PTMC hydrogels induces adverse outcomes in a femoral artery ligation model in athymic nu/nu mice

This study shows that delivering hASCs in hydrogels causes adverse outcomes in immunocompetent mice, unlike previous results in more immunocompromised models.

Sensitive Spatiotemporal Tracking of Spontaneous Metastasis in Deep Tissues via a Genetically-Encoded Magnetic Resonance Imaging Reporter

This paper develops an MRI reporter system using oatp1b3 to track metastasis in live mice with high resolution and sensitivity.

Gadolinium-free Magnetic Resonance Imaging of the Liver using an Oatp1-targeted Manganese(III) Porphyrin

This study develops a gadolinium-free MRI contrast agent targeting Oatp1 channels for liver imaging, showing improved relaxivity and specific signal changes in mice.

A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation

This study develops an iron-labeling method for patient-derived xenograft cells and validates it using bioluminescence and magnetic particle imaging to monitor tumor growth.

Molecular imaging reveals a high degree of cross-seeding of spontaneous metastases in a novel mouse model of synchronous bilateral breast cancer

This study uses a novel mouse model to show that spontaneous metastases in synchronous bilateral breast cancer originate from both primary tumors, revealing high cross-seeding of metastatic cells.

Visualizing tumour self-homing with magnetic particle imaging

This study uses magnetic particle imaging to detect and visualize tumor self-homing of iron-labeled CTCs in a murine breast cancer model.

A Safe Harbor-Targeted CRISPR/Cas9 Homology Independent Targeted Integration (HITI) System for Multi-Modality Reporter Gene-Based Cell Tracking

The paper develops a CRISPR/Cas9 HITI system for precise, safe harbor locus integration of multi-modality reporter genes for cell tracking.

Engineering self-homing circulating tumour cells as novel cancer theranostics

This study demonstrates that self-homing circulating tumor cells can target and treat metastatic breast cancer using gene therapy and bioluminescence imaging.

A human photoacoustic imaging reporter gene using the clinical dye indocyanine green.

This paper develops a photoacoustic imaging reporter system using the human Oatp1b3 protein and the clinical dye ICG, showing increased PAI signals in cells and mice.