J. J. Kelly

Targeted Acidosis Mediated Delivery of Antigenic MHC-Binding Peptides

This study uses pH-sensitive peptides to deliver MHC-binding antigens to cancer cells, enhancing T cell activation for immunotherapy.

Impact of Post-Translational Modification on MHC Peptide Binding and TCR Engagement

This study investigates how post-translational modifications affect MHC peptide binding and TCR engagement, revealing their impact on antigen presentation and potential implications for autoimmune diseases and tumor neoantigens.

Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macrophages

The paper measures antibiotic accumulation in phagosomes of live macrophages infected with Staphylococcus aureus to assess permeability differences between extracellular and intracellular environments.

Structure Activity Relationship of the Stem Peptide in Sortase A mediated Ligation from Staphylococcus aureus

The paper evaluates synthetic stem peptide analogs to assess their impact on sortase A activity in S. aureus, showing broad tolerability of substrate variations.

Sensitive Spatiotemporal Tracking of Spontaneous Metastasis in Deep Tissues via a Genetically-Encoded Magnetic Resonance Imaging Reporter

This paper develops an MRI reporter system using oatp1b3 to track metastasis in live mice with high resolution and sensitivity.

Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneity

The paper analyzes genetic and transcriptional profiles of glioblastomas, organoids, and cell lines to show variable retention of tumor heterogeneity in organoids and uniformity in cell lines.

Snapshots of actin and tubulin folding inside the TRiC chaperonin

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

Molecular imaging reveals a high degree of cross-seeding of spontaneous metastases in a novel mouse model of synchronous bilateral breast cancer

This study uses a novel mouse model to show that spontaneous metastases in synchronous bilateral breast cancer originate from both primary tumors, revealing high cross-seeding of metastatic cells.

A Safe Harbor-Targeted CRISPR/Cas9 Homology Independent Targeted Integration (HITI) System for Multi-Modality Reporter Gene-Based Cell Tracking

The paper develops a CRISPR/Cas9 HITI system for precise, safe harbor locus integration of multi-modality reporter genes for cell tracking.

Engineering self-homing circulating tumour cells as novel cancer theranostics

This study demonstrates that self-homing circulating tumor cells can target and treat metastatic breast cancer using gene therapy and bioluminescence imaging.