Coupling cryo-electron tomography with mixed-scale dense neural networks reveals re-organization of the invasion machinery of Toxoplasma gondii upon ionophore-stimulation
L.-a. Segev-Zarko, P. D. Dahlberg, S. Y. Sun, D. M. Pelt, C. Y. Kim, E. S. Egan, J. A. Sethian, W. Chiu, J. C. Boothroyd
The paper uses cryo-electron tomography and mixed-scale dense neural networks to analyze the reorganization of Toxoplasma gondii's invasion machinery upon ionophore stimulation, revealing structural changes and evolutionary conservation with Plasmodium falciparum.
PNAS Nexus · Sep 1, 2022Peer-reviewedCell Biology