Author

E. S. Egan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

C. Y. Kim· 3 shared B. Shakya· 2 shared J. C. Boothroyd· 2 shared S. Y. Sun· 2 shared W. Chiu· 2 shared A. K. Kongsomboonvech· 1 shared B. Baro· 1 shared C. Lin· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

C. Y. Kim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The base media formulation impacts the efficiency of ex-vivo erythropoiesis of primary human hematopoietic stem cells

N. A. Peterson, E. S. Egan

The study evaluates alternative IMDM products for ex-vivo erythropoiesis and finds FG0465 supports maximal erythroid cell proliferation and enucleation.

bioRxiv · Dec 24, 2023 · PreprintCell Biology

Plasmodium falciparum infection of primary human erythroblasts induces transcriptional changes associated with dyserythropoiesis

T. P. Feldman, Y. Ryan, E. S. Egan

This study identifies transcriptional changes in Plasmodium falciparum-infected erythroblasts across developmental stages, revealing dyserythropoiesis mechanisms.

bioRxiv · Apr 23, 2023 · PreprintMicrobiology

Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion

B. Baro, C. Y. Kim, C. Lin, A. K. Kongsomboonvech, M. Tetard, N. D. Salinas, N. H. Tolia, E. S. Egan

This study identifies CD44 as a co-receptor used by Plasmodium falciparum for erythrocyte invasion, showing it enhances parasite entry through cytoskeletal protein phosphorylation.

bioRxiv · Apr 12, 2023Microbiology

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum

S. Y. Sun, L.-a. S. Zarko, G. D. Pintilie, C. Y. Kim, S. R. Staggers, M. F. Schmid, E. S. Egan, W. Chiu, J. C. Boothroyd

This study uses cryogenic electron tomography to reveal new structural details of the apical complex in Plasmodium falciparum merozoites, including interactions between rhoptries and other structures.

bioRxiv · Sep 14, 2022Cell Biology

Coupling cryo-electron tomography with mixed-scale dense neural networks reveals re-organization of the invasion machinery of Toxoplasma gondii upon ionophore-stimulation

L.-a. Segev-Zarko, P. D. Dahlberg, S. Y. Sun, D. M. Pelt, C. Y. Kim, E. S. Egan, J. A. Sethian, W. Chiu, J. C. Boothroyd

The paper uses cryo-electron tomography and mixed-scale dense neural networks to analyze the reorganization of Toxoplasma gondii's invasion machinery upon ionophore stimulation, revealing structural changes and evolutionary conservation with Plasmodium falciparum.

PNAS Nexus · Sep 1, 2022Peer-reviewedCell Biology

Erythrocyte CD55 facilitates the internalization of Plasmodium falciparum parasites

B. Shakya, S. D. Patel, Y. Tani, E. S. Egan

This study identifies CD55 as a critical factor for Plasmodium falciparum parasite internalization into erythrocytes, showing it acts after rhoptry discharge and is distinct from other invasion receptors.

bioRxiv · Jul 27, 2020Microbiology

A common polymorphism in the druggable ion channel PIEZO1 is associated with protection from severe malaria

C. N. Nguetse, N. Purington, B. Shakya, E. R. Ebel, P. G. Kremsner, T. P. Velavan, E. S. Egan

This study identifies a PIEZO1 polymorphism associated with protection from severe malaria in humans, suggesting it as a potential druggable target.

bioRxiv · Jul 3, 2019Microbiology