Author

J. A. Siller-Farfan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

O. Dushek· 3 shared J. Burton· 2 shared J. Pettmann· 2 shared M. Kutuzov· 2 shared M. L. Dustin· 2 shared P. A. van der Merwe· 2 shared A. K. Jainarayanan· 1 shared A. Kvalvaag· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

O. Dushek

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 15, 2023

Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to study T cell antigen sensitivity by TCRs, CARs, and BiTEs

A. Patel, V. Andre, S. Bustamante Eguiguren…·O. Dushek

The paper uses CombiCells to compare T cell antigen sensitivity mediated by TCRs, CARs, and BiTEs and assess the impact of co-stimulation and co-inhibition receptors.

DOI 10.1101/2023.06.15.545075

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivOct 26, 2021

Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors.

J. Burton, J. A. Siller-Farfan, J. Pettmann…·O. Dushek

This study shows that CARs have lower antigen sensitivity than TCRs due to inefficient use of accessory receptors, and demonstrates ways to improve this sensitivity.

DOI 10.1073/pnas.2216352120

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

ImmunologybioRxivPreprintMay 29, 2021

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

P. F. Cespedes, A. K. Jainarayanan, L. Fernandez-Messina…·M. L. Dustin

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

DOI 10.1101/2021.05.29.445691

spatial transcriptomicsexperimental assay

𝕏 PostBluesky