Inferring B cell phylogenies from paired heavy and light chain BCR sequences with Dowser
C. G. Jensen, J. A. Sumner, S. H. Kleinstein, K. B. Hoehn
This study evaluates methods for inferring B cell phylogenies using paired heavy and light chain BCR sequences, finding that incorporating light chains improves accuracy and that maximum likelihood methods with separate partitions are most reliable.
bioRxiv · Sep 29, 2023Immunology