S.-K. Park

Target-based discovery of a broad spectrum flukicide

The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.

Exercise Mitigates Flow Recirculation and Activates Mechanosensitive Transcriptome to Uncover Endothelial SCD1-Catalyzed Anti-Inflammatory Metabolites

This study shows exercise reduces flow recirculation and activates SCD1 to produce anti-inflammatory metabolites in endothelial cells.

Activating P2Y1 receptors improves function in arteries with repressed autophagy

This study shows that activating P2Y1 receptors enhances arterial function in conditions where endothelial autophagy is suppressed.

Late-in-life treadmill-training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.

This study shows that treadmill training in old mice improves autophagy, protein aggregate clearance, and heart function.

Mechanism of praziquantel action at a parasitic flatworm ion channel

This study identifies the mechanism by which praziquantel activates a specific ion channel in parasitic flatworms, explaining its efficacy against some species but not others.

Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection

This study identifies miRNAs differentially expressed in hepatocellular carcinoma with vascular invasion and shows their association with poor prognosis after surgical resection.

Respiration enhances TDP-43 toxicity, but TDP-43 retains some toxicity in the absence of respiration

This paper shows that TDP-43 is more toxic in yeast under respiratory conditions but remains toxic without respiration, suggesting reactive oxygen species may enhance its toxicity.

An assessment of the interactions between climatic conditions and genetic characteristic on the agricultural performance of soybeans grown in Northeast Asia

This study assesses how climatic conditions and genetic traits influence soybean agricultural performance in Northeast Asia, finding that day length significantly affects flowering time and stem length, while yield varies by cultivar.