Author

K. B. Hoehn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:scRNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Assay:proteomics· 2

Frequent Co-Authors

S. H. Kleinstein· 5 shared O. G. Pybus· 3 shared R. Jiang· 3 shared K. C. OConnor· 2 shared M. L. Fichtner· 2 shared R. J. Nowak· 2 shared A. H. Ellebedy· 1 shared A. Kummer· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersImmunology

S. H. Kleinstein

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7 papers

Recent·Most cited

Inferring B cell phylogenies from paired heavy and light chain BCR sequences with Dowser

C. G. Jensen, J. A. Sumner, S. H. Kleinstein, K. B. Hoehn

This study evaluates methods for inferring B cell phylogenies using paired heavy and light chain BCR sequences, finding that incorporating light chains improves accuracy and that maximum likelihood methods with separate partitions are most reliable.

bioRxiv · Sep 29, 2023Immunology

The Physiological Landscape and Specificity of Antibody Repertoires

L. Csepregi, K. B. Hoehn, D. Neumeier, J. M. Taft, S. Friedensohn, C. R. Weber, A. Kummer, F. Sesterhenn, B. E. Correia, S. T. Reddy

This study analyzes antibody repertoires across multiple lymphoid organs in immunized mice, finding that strong humoral responses lead to consolidated, overlapping B-cell clones and a uniform but redundant physiological landscape.

bioRxiv · Sep 15, 2021 · PreprintImmunology

Elevated N-glycosylation of immunoglobulin G variable regions in myasthenia gravis highlights a commonality across autoantibody-associated diseases

C. Mandel-Brehm, M. L. Fichtner, R. Jiang, V. J. Winton, S. E. Vazquez, M. C. Pham, K. B. Hoehn, N. L. Kelleher, R. J. Nowak, S. H. Kleinstein, M. R. Wilson, J. L. DeRisi, K. C. OConnor

This study identifies elevated N-glycosylation in IgG variable regions in myasthenia gravis patients and shows it is not required for autoantigen binding.

bioRxiv · Mar 6, 2021Immunology

Human B cell lineages engaged by germinal centers following influenza vaccination are measurably evolving

K. B. Hoehn, J. S. Turner, F. I. Miller, R. Jiang, O. G. Pybus, A. H. Ellebedy, S. H. Kleinstein

The paper shows that influenza vaccination leads to measurable evolution in B cell lineages engaged by germinal centers, but not in blood lineages.

bioRxiv · Jan 6, 2021Immunology

Phylogenetic analysis of migration, differentiation, and class switching in B cells

K. B. Hoehn, O. G. Pybus, S. H. Kleinstein

The paper develops three summary statistics to infer migration, differentiation, and isotype switching in B cells using BCR sequence data and applies them to HIV and food allergy datasets.

bioRxiv · May 30, 2020Immunology

Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses

R. Jiang, M. L. Fichtner, K. B. Hoehn, P. Stathopoulos, R. J. Nowak, S. Kleinstein, K. C. OConnor

The paper identifies persistent autoantibody-producing B cell clones in rituximab-treated myasthenia gravis patients during relapses, showing incomplete B cell depletion.

bioRxiv · Jan 15, 2020Immunology

Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

K. B. Hoehn, J. A. Vander Heiden, J. Q. Zhou, G. Lunter, O. G. Pybus, S. H. Kleinstein

This study introduces a hierarchical phylogenetic framework to analyze B cell repertoires, revealing age-related changes in SHM motifs and a link between tree length and negative selection.

bioRxiv · Feb 25, 2019Immunology