J. A. Winston

Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids which attenuates NF-κB signaling via bile acid activated receptors

This paper shows that UDCA reduces inflammation during CDI by altering bile acids and modulating NF-κB signaling through FXR and TGR5 receptors.

Characterization of C. difficile strains isolated from companion animals and the associated changes in the host fecal microbiota

This study identifies C. difficile strains in companion animals and their impact on host fecal microbiota, showing potential zoonotic transmission and shared ribotypes with human infections.

Secondary bile acid ursodeoxycholic acid (UDCA) alters weight, the gut microbiota, and the bile acid pool in conventional mice

This study shows that ursodiol administration in mice causes weight loss and changes in gut microbiota and bile acid pools.