A. D. Patterson

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST identifies microbial-derived metabolites and their producers using taxonomically-informed mass spectrometry data without prior knowledge.

Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations

This study identifies metformin and T2D as factors influencing gut fungal communities across human populations.

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.

Selenium-dependent metabolic reprogramming during inflammation and resolution

This study shows selenium enhances metabolic reprogramming in macrophages during inflammation resolution by modulating key metabolic pathways.

Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health

The paper compares gut microbiomes of East Asian and White individuals in the same geographic area, finding ethnic differences linked to metabolic health and independent of diet.

Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids which attenuates NF-κB signaling via bile acid activated receptors

This paper shows that UDCA reduces inflammation during CDI by altering bile acids and modulating NF-κB signaling through FXR and TGR5 receptors.

Secondary bile acid ursodeoxycholic acid (UDCA) alters weight, the gut microbiota, and the bile acid pool in conventional mice

This study shows that ursodiol administration in mice causes weight loss and changes in gut microbiota and bile acid pools.