C. M. Theriot

Dietary protein source alters gut microbiota composition and function

This study shows that different dietary protein sources alter gut microbiota composition and function in mice, affecting amino acid and mucus degradation processes.

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

This study examines changes in microbiome, metabolome, and lipidome after fecal microbiota transplantation for recurrent C. difficile infection, identifying lipid and bile acid shifts linked to treatment success.

Large Quantities of Bacterial DNA and Protein in Common Dietary Protein Source Used in Microbiome Studies

This study identifies microbial DNA and protein in casein-based diets, showing they contribute to microbiome measurements and are absent in other protein sources.

Loss of Bacteroides thetaiotaomicron bile acid altering enzymes impact bacterial fitness and the global metabolic transcriptome

This study investigates how Bacteroides thetaiotaomicron's bile acid altering enzymes affect its fitness and metabolic transcriptome under bile acid exposure.

The microbial derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota

This study shows that bile acid epimers iLCA and iaLCA inhibit C. difficile growth and toxin activity while sparing gut commensals.

Tauroursodeoxycholic acid inhibits Clostridioides difficile toxin induced apoptosis

This study shows that taurine-conjugated ursodeoxycholic acid (TUDCA) inhibits C. difficile toxin-induced apoptosis in Caco-2 cells, while unconjugated UDCA does not, highlighting the importance of bile acid conjugation in CDI therapy.

Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis

The paper identifies bile salt hydrolase (BSH) substrate preferences and shows they inhibit C. difficile by altering bile acid pools in CDI models.

The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia

This study investigates how trans-4-hydroxyproline affects the metabolism of C. difficile and commensal Clostridia, revealing differential gene expression and microbiota changes in mice.

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

This study shows C. difficile uses toxin-induced inflammation to alter host nutrient availability and outcompete Bacteroides by utilizing collagen-derived amino acids.

Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids which attenuates NF-κB signaling via bile acid activated receptors

This paper shows that UDCA reduces inflammation during CDI by altering bile acids and modulating NF-κB signaling through FXR and TGR5 receptors.

Strain-dependent inhibition of Clostridioides difficile by commensal Clostridia encoding the bile acid inducible (bai) operon

This study shows that commensal Clostridia with the bai operon inhibit C. difficile growth in a strain-dependent manner through bile acid conversion, but C. difficile outcompetes them in co-culture.

Characterization of C. difficile strains isolated from companion animals and the associated changes in the host fecal microbiota

This study identifies C. difficile strains in companion animals and their impact on host fecal microbiota, showing potential zoonotic transmission and shared ribotypes with human infections.

Secondary bile acid ursodeoxycholic acid (UDCA) alters weight, the gut microbiota, and the bile acid pool in conventional mice

This study shows that ursodiol administration in mice causes weight loss and changes in gut microbiota and bile acid pools.

Inter-individual Recovery Of The Microbiota And Metabolome Over Time Following Fecal Microbiota Transplantation In Patients With Recurrent Clostridium difficile Infection

This study examines microbiota and metabolome recovery in patients with recurrent CDI after FMT, identifying microbial associations with metabolite changes and individualized recovery patterns.