J. Adam

Multimodal CustOmics: A Unified and Interpretable Multi-Task Deep Learning Framework for Multimodal Integrative Data Analysis in Oncology

This paper introduces a deep learning framework for integrating multimodal cancer data, showing improved performance and interpretability across TCGA datasets.

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Sources of genomic diversity in the self-fertile plant pathogen, Sclerotinia sclerotiorum, and consequences for resistance breeding

This study analyzes genomic diversity and aggressiveness in Sclerotinia sclerotiorum isolates from canola fields, finding high haplotype diversity and mycelium compatibility patterns linked to geographic and environmental factors.

Variation in the plasma membrane monoamine transporter (PMAT, encoded in SLC29A4) and organic cation transporter 1 (OCT1, encoded in SLC22A1) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

This study investigates the association between genetic variants in PMAT and OCT1 transporters and metformin gastrointestinal intolerance in type 2 diabetes patients.