Author

J. Aiken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. L. F. Holzbaur· 2 shared C. Kim· 1 shared D. A. Kramer· 1 shared D. Dou· 1 shared D. McKenzie· 1 shared E. Monleon· 1 shared H. Wille· 1 shared J. van der Merwe· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

E. L. F. Holzbaur

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Fibronectin: a natural barrier against prion infection

M. C. Garza, S. G. Kang, C. Kim, E. Monleon, J. van der Merwe, D. A. Kramer, R. Fahlman, V. Sim, J. Aiken, D. McKenzie, L. M. Cortez, H. Wille

This study identifies fibronectin as a natural barrier against prion infection by showing its association with PrPSc and its ability to reduce prion infectivity in vitro and in tissues.

bioRxiv · Aug 31, 2023 · PreprintBiochemistry

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

J. Aiken, E. L. F. Holzbaur

This study identifies spastin's role in enhancing microtubule dynamics to pattern axons for presynaptic cargo delivery in human neurons.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

D. Dou, J. Aiken, E. L. F. Holzbaur

This study shows that hyperactive LRRK2 impairs synaptic vesicle precursor trafficking by phosphorylating RAB3A, leading to disrupted synaptic protein delivery and potential non-motor PD symptoms.

bioRxiv · Jul 25, 2023Cell Biology