Author

J. Ambrose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Eades· 1 shared A. Kauffmann· 1 shared A. Olou· 1 shared B. Bye· 1 shared D. A. Ruddy· 1 shared D. Pei· 1 shared E. Kurth· 1 shared E. R. McDonald· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. Eades

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2 papers

Recent·Most cited

Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer

R. M. Walsh, J. Ambrose, F. Messaggio, B. Bye, A. Eades, J. Jack, M. Ruckert, A. Olou, P. Chalise, D. Pei, M. VanSaun

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

bioRxiv · Aug 15, 2023 · PreprintCancer Biology

Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia

F. Rago, L. U. Rodrigues, M. Bonney, K. Sprouffske, E. Kurth, G. Elliott, J. Ambrose, P. Aspesi, J. Oborski, J. T. Chen, E. R. McDonald, F. A. Mapa, D. A. Ruddy, A. Kauffmann, T. Abrams, , Z. Jagani

This study shows that dual BRG1/BRM ATPase inhibitors are effective against AML cell lines, revealing broad SWI/SNF dependencies and suggesting therapeutic potential.

bioRxiv · Apr 23, 2021Cancer Biology