R. M. Walsh

Visualizing chaperone-mediated multistep assembly of the human 20S proteasome

The paper uses cryo-EM to visualize the assembly of the human 20S proteasome, revealing how chaperones and propeptides guide subunit incorporation and proteasome activation.

Structure of an insect gustatory receptor

The paper determines the structure of BmGr9, an insect gustatory receptor, and compares it to olfactory receptors to understand ligand specificity.

Combined PI3K and MAPK inhibition synergizes to suppress PDAC

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

Structural impact on SARS-CoV-2 spike protein by D614G substitution

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

Distinct conformational states of SARS-CoV-2 spike protein

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.