Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response
J. Krakowiak, X. Zheng, N. Patel, J. Anandhakumar, K. Valerius, D. S. Gross, A. S. Khalil, D. Pincus
The paper validates a mathematical model of the yeast heat shock response by showing Hsp70-mediated negative feedback regulates Hsf1 activity through specific binding sites and domains.
bioRxiv · Aug 31, 2017Biochemistry