N. Patel

Performance effects from different shutdown methods of three electrode materials for the power-to-gas application with electromethanogenesis

This study evaluates the performance of three electrode materials during shutdowns in microbial electrochemical systems for electromethanogenesis, finding that nickel cathodes show the fastest recovery.

Flexible Cell Modeling Using Frequency Modulation

The paper introduces a Frequency Modulation model for real-time cell and tissue emulation on FPGA, capable of replicating detailed cell models and simulating cellular dysfunctions.

Reduced Telomerase Interaction with Telomeres Alters Meiotic Chromosome Motion and Gamete Viability

This study shows that reduced telomerase interaction with telomeres in yeast affects meiotic chromosome motion and gamete viability by altering recombination and cytoskeletal forces.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord

The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.

Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

XBB.1.5 Spike Protein COVID-19 Vaccine Induces Broadly Neutralizing and Cellular Immune Responses Against EG.5.1 and Emerging XBB Variants

This study shows that a monovalent XBB.1.5 spike protein vaccine induces broader neutralizing antibodies and stronger cellular immunity against multiple SARS-CoV-2 variants compared to bivalent vaccines.

Real-time Quantification of in vivo cerebrospinal fluid velocity using fMRI inflow effect

This paper develops a method to estimate real-time CSF flow velocity using fMRI inflow effect, showing nonlinear relationships and validating it in human volunteers.

NVX-CoV2373 ancestral and NVX-CoV2540 BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters

This study evaluates the efficacy of NVX-CoV2373 and NVX-CoV2540 nanoparticle vaccines against the Omicron BA.5 variant in Syrian hamsters, showing reduced viral infection and better protection compared to mRNA vaccines.

Frequent allopolyploidy with distant progenitors in the moss genera Physcomitrium and Entosthodon (Funariaceae) identified via subgenome phasing of targeted nuclear genes.

The paper identifies allopolyploidy in moss species using subgenome phasing of targeted nuclear genes, revealing hybrid origins and new lineages.

Naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

The paper identifies metabolic and genetic adaptations in naked mole-rats that confer resistance to cardiovascular disease and hypoxia.

Atomic Models of All Major Trans-Envelope Complexes Involved in Lipid Trafficking in Escherichia Coli Constructed Using a Combination of AlphaFold2, AF2Complex, and Membrane Morphing Simulations

The paper constructs atomic models of four lipid transport TECs in E. coli using AlphaFold2, AF2Complex, and membrane morphing simulations.

Characterization and Validation of a Middle-Down Hydrophobic Interaction Chromatography Method to Monitor Methionine Oxidation in IgG1

This paper develops and validates a middle-down hydrophobic interaction chromatography method to monitor methionine oxidation in IgG1, demonstrating its specificity, linearity, precision, and accuracy.

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis

The paper shows oversized cells increase proteasome-mediated protein degradation to maintain size homeostasis by reducing growth efficiency.

A genetic compensatory mechanism regulated by c-Jun and Mef2d modulates the expression of distinct class IIa HDACs to ensure peripheral nerve myelination and repair

The paper identifies a genetic compensatory mechanism in Schwann cells involving c-Jun and Mef2d that modulates class IIa HDAC expression to support peripheral nerve myelination and repair.

In vitro Functional Analysis of pgRNA Sites Regulating Assembly of Hepatitis B Virus.

The paper investigates RNA sequence/structure motifs regulating HBV genome assembly in vitro, showing their role in nucleocapsid formation and confirming interactions via X-ray RNA footprinting.

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands

The paper identifies small ligands that bind RNA packaging signals in Hepatitis B Virus, inhibiting nucleocapsid assembly and suggesting new anti-viral drug targets.

Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice

This study shows that deleting Bmal1 in colon epithelial cells reduces trabecular and cortical bone in male mice, but not females.

Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies

This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and QuadrivalentSeasonal Influenza Hemagglutinin Nanoparticles with Matrix-M Adjuvant

This paper evaluates a combination vaccine against seasonal influenza and SARS-CoV-2 in animal models, showing it induces protective immune responses and prevents viral replication and disease.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein

This study evolved a bacterial protein into an artificial nucleocapsid that packages and protects mRNA, revealing evolutionary parallels to viruses and potential applications in vaccine delivery.

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.