Author

J. Aspden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. Whitehouse· 3 shared J. C. Murphy· 2 shared T. J. Mottram· 2 shared A. Macdonald· 1 shared A. R. Leach· 1 shared B. Baquero-Perez· 1 shared C. J. Trevelyan· 1 shared E. Harrington· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Whitehouse

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EMG1 methyltransferase activity regulates ribosome occupancy at viral uORFs

E. M. Harrington, J. C. Murphy, J. Aspden, A. Whitehouse

This study shows that EMG1 methyltransferase activity regulates ribosome occupancy at KSHV uORFs, affecting viral protein expression and infectious virus production.

bioRxiv · Jul 23, 2024 · PreprintMicrobiology

m6A regulates the stability of cellular transcripts required for efficient KSHV lytic replication

O. Manners, B. Baquero-Perez, T. J. Mottram, I. D. Yonchev, C. J. Trevelyan, M. R. Patterson, A. Macdonald, S. A. Wilson, J. Aspden, A. Whitehouse

This study shows m6A modification stabilizes GPRC5A mRNA, which promotes KSHV lytic replication by enhancing NF-κB signaling.

bioRxiv · Feb 9, 2023 · PreprintMicrobiology

Kaposi's sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs

J. C. Murphy, S. Schumann, E. Harrington, E. Vasconcelos, T. J. Mottram, J. Aspden, A. Whitehouse

This study shows Kaposi's sarcoma-associated herpesvirus manipulates host ribosome composition to create specialised ribosomes that enhance translation of viral lytic mRNAs.

bioRxiv · Mar 11, 2022Microbiology

Ribosome fingerprinting with a solid-state nanopore

M. Raveendran, A. R. Leach, T. S. Hopes, J. Aspden, P. Actis

This study uses solid-state nanopores to distinguish 80S ribosomes from polysomes in human and Drosophila cells based on peak amplitude and dwell time.

bioRxiv · Aug 7, 2020Biophysics