Author

T. J. Mottram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Whitehouse· 4 shared A. Macdonald· 2 shared J. Aspden· 2 shared K. L. Harper· 2 shared M. R. Patterson· 2 shared B. Baquero-Perez· 1 shared B. Foster· 1 shared C. A. Anene· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

A. Whitehouse

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Author profile →

4 papers

Recent·Most cited

m6A regulates the stability of cellular transcripts required for efficient KSHV lytic replication

O. Manners, B. Baquero-Perez, T. J. Mottram, I. D. Yonchev, C. J. Trevelyan, M. R. Patterson, A. Macdonald, S. A. Wilson, J. Aspden, A. Whitehouse

This study shows m6A modification stabilizes GPRC5A mRNA, which promotes KSHV lytic replication by enhancing NF-κB signaling.

bioRxiv · Feb 9, 2023 · PreprintMicrobiology

Pseudouridine prevalence in Kaposi's sarcoma associated herpesvirus transcriptome reveals an essential mechanism for viral replication

T. J. Mottram, K. L. Harper, E. J. Vasconcelos, C. A. Anene, A. Whitehouse

This study identifies pseudouridylation as essential for Kaposi's sarcoma-associated herpesvirus replication by analyzing its role in viral RNA stability and protein interactions.

bioRxiv · Jan 31, 2023Microbiology

Kaposi's sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs

J. C. Murphy, S. Schumann, E. Harrington, E. Vasconcelos, T. J. Mottram, J. Aspden, A. Whitehouse

This study shows Kaposi's sarcoma-associated herpesvirus manipulates host ribosome composition to create specialised ribosomes that enhance translation of viral lytic mRNAs.

bioRxiv · Mar 11, 2022Microbiology

CircHIPK3 dysregulation of the miR-30c/DLL4 axis is essential for KSHV lytic replication

K. L. Harper, T. J. Mottram, C. A. Arene, B. Foster, M. R. Patterson, E. McDonnell, A. Macdonald, D. Westhead, A. Whitehouse

The paper identifies a host ncRNA regulatory network involving circHIPK3 and miR-30c/DLL4 that is essential for KSHV lytic replication in B cells.

bioRxiv · Oct 7, 2021Microbiology