Author

J. B. Lees-Shepard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. N. Economides· 2 shared E. J. Goebel· 2 shared S. Aykul· 2 shared V. Idone· 2 shared A. Dimitriou· 1 shared A. J. Murphy· 1 shared A. Rafique· 1 shared C. J. Cunanan· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

A. N. Economides

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Author profile →

2 papers

Recent·Most cited

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch

W. W. Hom, S. Aykul, L. Panagis, K. Patel, S. Brydges, E. J. Goebel, K. N. Lydon, J. B. Lees-Shepard, S. J. Hatsell, V. Idone, A. N. Economides

The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.

bioRxiv · Jan 29, 2024 · PreprintCell Biology

The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors

S. Aykul, R. A. Corpina, E. J. Goebel, C. J. Cunanan, A. Dimitriou, H. Kim, Q. Zhang, A. Rafique, R. Leidich, X. Wang, J. McClain, J. Jimenez, K. C. Nannuru, N. J. Rothman, J. B. Lees-Shepard, , V. Idone

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

bioRxiv · May 28, 2020 · PreprintCell Biology