Author

J. C. Cochran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

B. C. Walker· 2 shared C. E. Walczak· 1 shared C. G. Connell· 1 shared H. Park· 1 shared H. Zhu· 1 shared J. S. Eskew· 1 shared K. M. Bell· 1 shared W. Tempel· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

8 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

B. C. Walker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Switch-1 Instability at the Active Site Decouples ATP Hydrolysis from Force Generation in Myosin II

B. C. Walker, C. E. Walczak, J. C. Cochran

This study shows that altering switch-1's interaction with a divalent metal cofactor decouples ATP hydrolysis from force generation in myosin II.

bioRxiv · Sep 10, 2020Biochemistry

The large loop-8 insert in Saccharomyces cerevisiae kinesin-5 Cin8 is necessary and sufficient to promote noncanonical microtubule interactions

K. M. Bell, J. C. Cochran

The study shows that the loop-8 insert in Cin8 is necessary and sufficient for noncanonical microtubule binding, as demonstrated through mutagenesis and binding assays.

bioRxiv · Jan 20, 2019 · PreprintBiochemistry

Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function

B. C. Walker, W. Tempel, H. Zhu, H. Park, J. C. Cochran

This study compares the ATPase mechanisms and microtubule interactions of NOD and KID chromokinesins, revealing distinct structural and biochemical pathways for similar functions during cell division.

bioRxiv · Jan 15, 2019Biochemistry

Error sensitivity and optimization of steady-state kinetic parameters using multidimensional chemical kinetic analysis

J. S. Eskew, C. G. Connell, J. C. Cochran

This study develops a method to determine Michaelis-Menten constants from multidimensional enzyme kinetic data and evaluates its error tolerance.

bioRxiv · Jan 14, 2019 · PreprintBiochemistry