Author

C. E. Walczak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. C. Ems-McClung· 2 shared B. C. Walker· 1 shared C. Moe· 1 shared H. Zong· 1 shared J. C. Cochran· 1 shared J. C. Smith· 1 shared J. Pilrose· 1 shared J. R. Stout· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

S. C. Ems-McClung

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MCAK Inhibitors Induce Aneuploidy in Triple Negative Breast Cancer Models

J. C. Smith, S. Husted, J. Pilrose, S. C. Ems-McClung, J. R. Stout, R. L. Carpenter, C. E. Walczak

This study identifies three MCAK inhibitors that induce aneuploidy in TNBC cells, reduce clonogenic survival, and sensitize cells to paclitaxel.

bioRxiv · May 31, 2023Cancer Biology

Switch-1 Instability at the Active Site Decouples ATP Hydrolysis from Force Generation in Myosin II

B. C. Walker, C. E. Walczak, J. C. Cochran

This study shows that altering switch-1's interaction with a divalent metal cofactor decouples ATP hydrolysis from force generation in myosin II.

bioRxiv · Sep 10, 2020Biochemistry

Spatial Regulation of MCAK Promotes Cell Polarization and Focal Adhesion Turnover to Drive Robust Cell Migration

H. Zong, M. Hazelbaker, C. Moe, S. C. Ems-McClung, K. Hu, C. E. Walczak

This study shows that MCAK's spatial distribution regulates cell migration by affecting MT dynamics, cell polarization, and focal adhesion turnover in RPE-1 cells.

bioRxiv · Apr 30, 2020Cell Biology

RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking

S. E. Ems-McClung, M. Emch, S. Zhang, S. Mahnoor, L. N. Weaver, C. E. Walczak

The paper shows RanGTP creates an effector gradient of XCTK2 and importin α/β that regulates spindle microtubule cross-linking by modulating XCTK2 activity.

bioRxiv · Jun 8, 2019Cell Biology