Author

J. C. Rosenbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Xenopus· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. E. Carlson· 4 shared R. E. Bainbridge· 2 shared C. Lara-Santos· 1 shared K. G. Sharp· 1 shared K. M. Komondor· 1 shared M. Tembo· 1 shared P. Sau· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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4 shared papersPhysiology

A. E. Carlson

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Author profile →

4 papers

Recent·Most cited

Xenopus laevis lack the critical sperm factor PLCζ

R. E. Bainbridge, J. C. Rosenbaum, P. Sau, A. E. Carlson

This study investigates whether Xenopus laevis sperm express an unannotated PLCZ1 ortholog, finding none and suggesting PLCZ1 may have been lost in the Xenopus lineage.

bioRxiv · Feb 2, 2023 · PreprintPhysiology

Studying metal-protein interactions using fluorescent protein indicators

J. C. Rosenbaum, A. E. Carlson

This study develops and characterizes fluorescent protein reporters to detect metal-protein interactions, finding differential metal binding affinities and the role of glutathione in modulating these interactions.

bioRxiv · Oct 13, 2022 · PreprintBiochemistry

TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs

K. M. Komondor, R. E. Bainbridge, K. G. Sharp, J. C. Rosenbaum, A. E. Carlson

This study investigates the mechanism by which fertilization activates PLC in Xenopus laevis eggs to trigger the fast block to polyspermy, finding no effect from inhibitors of PLCγ or Gq/11 pathways.

bioRxiv · Aug 30, 2022Physiology

PIP2 and Ca2+ regulation of TMEM16A currents in excised inside-out patches

M. Tembo, C. Lara-Santos, J. C. Rosenbaum, A. E. Carlson

This study investigates how intracellular Ca2+ affects the rundown rate of TMEM16A currents in excised patches by modulating PLC activity and PI(4,5)P2 levels.

bioRxiv · Aug 30, 2022 · PreprintPhysiology