TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs
K. M. Komondor, R. E. Bainbridge, K. G. Sharp, J. C. Rosenbaum, A. E. Carlson
This study investigates the mechanism by which fertilization activates PLC in Xenopus laevis eggs to trigger the fast block to polyspermy, finding no effect from inhibitors of PLCγ or Gq/11 pathways.
bioRxiv · Aug 30, 2022Physiology