The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess
D. Nasteska, F. Cuozzo, A. Thakker, R. Bany Bakar, R. Westbrook, I. Akerman, J. Cantley, D. A. Tennant, D. J. Hodson
This paper shows that PHD3 deletion in beta-cells impairs glucose homeostasis under high fat diet by altering fuel utilization and metabolic pathways.
bioRxiv · Apr 30, 2020 · PreprintPhysiology