D. A. Tennant

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

The glucocorticoid dexamethasone inhibits HIF-1alpha stabilisation and metabolic reprogramming in lipopolysaccharide-stimulated primary macrophages.

This study shows dexamethasone inhibits HIF-1α stabilization and reduces GLUT1 expression in lipopolysaccharide-stimulated macrophages, impairing glucose uptake and metabolic reprogramming.

A new paradigm of intracrine free fatty acid receptor 4 signaling at lipid droplets

The paper shows FFA4, a GPCR, signals from lipid droplet-associated membranes in adipocytes, providing localized feedback to regulate lipolysis.

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS

The paper shows that residual Complex I activity sustains glutamate catabolism and mtSLP during acute anoxia by oxidizing NADH with endogenous quinones, bypassing OXPHOS.

Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model.

This paper develops an in-silico metabolic model of a co-culture system to better understand tumor metabolism and its interactions with surrounding cells.

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

This paper shows that PHD3 deletion in beta-cells impairs glucose homeostasis under high fat diet by altering fuel utilization and metabolic pathways.

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice

This study examines the metabolic and mitochondrial adaptations in H6PDH knockout mice, showing activation of the NRK2 NAD+ salvage pathway and its limited effect on mitigating myopathy and mitochondrial dysfunction.