Author

A. Thakker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Pitt· 2 shared C. Spickett· 2 shared D. A. Tennant· 2 shared A. J. Drake· 1 shared B. Lucendo Villarin· 1 shared C. Ludwig· 1 shared D. C. Hay· 1 shared D. J. Hodson· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. Pitt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles, S. Wernig-Zorc, J. P. Thomson, P. D. Walker, A. Thakker, G. G. Lavery, C. Ludwig, D. A. Tennant, D. C. Hay, A. J. Drake

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

bioRxiv · Jun 23, 2020Biochemistry

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

D. Nasteska, F. Cuozzo, A. Thakker, R. Bany Bakar, R. Westbrook, I. Akerman, J. Cantley, D. A. Tennant, D. J. Hodson

This paper shows that PHD3 deletion in beta-cells impairs glucose homeostasis under high fat diet by altering fuel utilization and metabolic pathways.

bioRxiv · Apr 30, 2020 · PreprintPhysiology

Serial coupling of chromatographic columns having orthogonal selectivity to improve the coverage of oxidised lipidome for mass spectrometry analysis

A. Thakker, C. Spickett, A. Pitt

This study improves OxPL detection by serially coupling chromatographic columns, enhancing coverage of oxidized lipid species in mass spectrometry analysis.

bioRxiv · Sep 12, 2019 · PreprintBiochemistry

A Targeted Mass Spectrometry Approach to detect and quantify Oxidised Phospholipids in plasma samples of Diabetic patients

A. Thakker, C. Spickett, A. Pitt

This paper develops targeted mass spectrometry methods to detect and quantify oxidised phospholipids in diabetic patients' plasma, identifying short-chain oxidation products but finding no statistically significant abundance differences between diabetic and healthy samples.

bioRxiv · Sep 12, 2019 · PreprintBiochemistry