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10 papers
Recent·Most cited
P. Vardaka, E. Page, M. Care, S. Stephenson, B. Kemp, M. Umpierrez, E. O'Callaghan, A. Mabbutt, R. Owen, D. J. Hodson, G. M. Doody, R. Tooze
This study shows that enforced MYC expression alters transcriptional programs and metabolic shifts during human plasma cell differentiation without causing transformation.
bioRxiv · Apr 18, 2024 · PreprintCell Biology
M. Montaner, J. Denom, V. Simon, W. Jiang, M. K. Holt, D. Brierley, C. Rouch, E. Foppen, N. Kassis, D. Jarriault, D. Khan, L. Eygret, F. Mifsud, D. J. Hodson, J. Broichhagen, , C. Magnan
This study shows that GLP-1 receptor activation in the olfactory bulb enhances insulin secretion via a sympathetic pathway involving the paraventricular nucleus.
bioRxiv · Aug 28, 2023 · PreprintPhysiology
F. Cuozzo, K. Viloria, A. H. Shilleh, D. Nasteska, C. Frazer-Morris, Z. Jiao, A. Boufersaoui, B. Marzullo, H. R. Smith, C. Bonner, J. Kerr-Conte, F. Pattou, R. Nano, L. Piemonti, P. R. Johnson, , D. J. Hodson
The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.
bioRxiv · Dec 21, 2022 · PreprintPhysiology
Y. Mugabo, C. Zhao, J. J. Tan, A. Ghosh, S. A. Campbell, E. Fadzeyeva, F. Pare, S. S. Pan, M. Galipeau, J. Ast, J. Broichhagen, D. J. Hodson, E. E. Mulvihill, S. Petropoulos, G. E. Lim
This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.
bioRxiv · Oct 17, 2021Physiology
S. E. Arthur, J. Gao, S. Healy, C. K. Rushton, N. Thomas, L. K. Hilton, K. Dreval, J. Tang, M. Alcaide, R. Cojocaru, A. Mottok, A. Telenius, P. Unrau, W. H. Wilson, L. M. Staudt, , R. D. Morin
This study identifies non-coding NFKBIZ 3' UTR mutations as drivers of DLBCL growth and resistance to NF-κB-targeted therapies, suggesting their potential as biomarkers.
bioRxiv · May 22, 2021 · PreprintCancer Biology
V. Kravets, J. M. Dwulet, W. E. Schleicher, D. J. Hodson, A. M. Davis, L. Pyle, R. A. Piscopio, M. Sticco-Ivins, R. K. Benninger
The paper identifies and characterizes first responder beta-cells in pancreatic islets that drive the first-phase calcium response to glucose.
bioRxiv · Dec 22, 2020Biophysics
D. Nasteska, F. Cuozzo, A. Thakker, R. Bany Bakar, R. Westbrook, I. Akerman, J. Cantley, D. A. Tennant, D. J. Hodson
This paper shows that PHD3 deletion in beta-cells impairs glucose homeostasis under high fat diet by altering fuel utilization and metabolic pathways.
bioRxiv · Apr 30, 2020 · PreprintPhysiology
K. Viloria, D. Nasteska, L. J. B. Briant, S. Helsing, D. Larner, N. H. F. Fine, F. B. Ashford, G. da Silva Xavier, M. Jimenez Ramos, J. E. Manning Fox, P. E. MacDonald, I. Akerman, G. G. Lavery, C. Flaxman, N. G. Morgan, , D. J. Hodson
This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.
bioRxiv · Dec 19, 2019 · PreprintPhysiology
J. Ast, A. Arvaniti, N. H. F. Fine, D. Nasteska, F. B. Ashford, Z. Stamataki, Z. Koszegi, A. Bacon, S. Trapp, B. J. Jones, B. Hastoy, A. Tomas, C. Reissaus, A. K. Linnemann, E. D'Este, , D. J. Hodson
The paper introduces LUXendin peptides that label and visualize endogenous GLP1R with high specificity, revealing receptor organization and dynamics.
bioRxiv · May 8, 2019Cell Biology
R. Caeser, M. Di Re, J. A. Krupka, J. Gao, M. Lara-Chica, J. M. L. Dias, S. L. Cooke, R. Fenner, Z. Usheva, H. Runge, P. A. Beer, H. Eldaly, H.-K. Pak, C.-S. Park, G. Vassiliou, , D. J. Hodson
This study generates synthetic lymphoma models by genetically modifying primary human B cells to investigate oncogenic mutations in DLBCL.
bioRxiv · Apr 26, 2019 · PreprintCancer Biology