NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype
F. Bocci, S. C. Tripathi, S. Vilchez Mercedes, J. T. George, J. Casabar, P. K. Wong, S. Hanash, H. Levine, J. N. Onuchic, M. K. Jolly
This study shows NRF2 stabilizes a hybrid epithelial/mesenchymal phenotype by upregulating both E-cadherin and ZEB, and correlates this phenotype with poor survival in cancer.
bioRxiv · May 10, 2019Cancer Biology