Cancer BiologybioRxiv
NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype
F. Bocci, S. C. Tripathi, S. Vilchez Mercedes…·M. K. Jolly
This study shows NRF2 stabilizes a hybrid epithelial/mesenchymal phenotype by upregulating both E-cadherin and ZEB, and correlates this phenotype with poor survival in cancer.
DOI 10.1093/intbio/zyz021