Author

P. K. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. C. Rowat· 1 shared B. Chen· 1 shared C. Ly· 1 shared E. J. Zudock· 1 shared F. Bocci· 1 shared H. Levine· 1 shared J. C. Liao· 1 shared J. Casabar· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

A. C. Rowat

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Author profile →

3 papers

Recent·Most cited

Machine Learning Workflow for Single-Cell Antimicrobial Susceptibility Testing of Klebsiella pneumoniae to Meropenem in Sub-Doubling Time

K. C. Tjandra, N. C. Ram-Mohan, M. Roshardt, Z. Qu, E. J. Zudock, K. E. Mach, O. Erminaga, J. C. Liao, S. Yang, P. K. Wong

This paper develops a machine learning workflow to predict antimicrobial susceptibility and MIC of Klebsiella pneumoniae to meropenem using single-cell morphological features within sub-doubling time.

bioRxiv · Nov 3, 2022 · PreprintMicrobiology

Transient nuclear deformation primes epigenetic state and promotes cell reprogramming

Y. Song, J. Soto, B. Chen, W. Zhao, T. Hoffman, N. Zhu, Q. Peng, C. Ly, P. K. Wong, Y. Wang, A. C. Rowat, S. K. Kurdistani, S. Li

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

bioRxiv · May 19, 2021Biophysics

NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype

F. Bocci, S. C. Tripathi, S. Vilchez Mercedes, J. T. George, J. Casabar, P. K. Wong, S. Hanash, H. Levine, J. N. Onuchic, M. K. Jolly

This study shows NRF2 stabilizes a hybrid epithelial/mesenchymal phenotype by upregulating both E-cadherin and ZEB, and correlates this phenotype with poor survival in cancer.

bioRxiv · May 10, 2019Cancer Biology