Author

J. Cate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Lapinaite· 1 shared E. Montabana· 1 shared F. R. Ward· 1 shared J. A. Doudna· 1 shared K. McClure· 1 shared R. Dullea· 1 shared S. Liras· 1 shared S. T. Chang· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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1 shared paperBiochemistry

A. Lapinaite

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2 papers

Recent·Most cited

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

W. Li, F. R. Ward, K. McClure, S. T. Chang, E. Montabana, S. Liras, R. Dullea, J. Cate

This study identifies how PF-846 selectively stalls ribosome translation by binding in a specific pocket and altering nascent chain path, revealing a mechanism for targeted protein inhibition.

bioRxiv · Jan 9, 2019Biophysics

Programmable RNA recognition using a CRISPR-associated Argonaute

A. Lapinaite, J. A. Doudna, J. Cate

This paper shows that modifying guide RNAs with 5-BrdU enhances the specificity and affinity of CRISPR-associated Argonaute RNPs for RNA targets, enabling single-nucleotide discrimination and RNA editing detection.

bioRxiv · Jan 19, 2018Biochemistry