Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
W. Li, F. R. Ward, K. McClure, S. T. Chang, E. Montabana, S. Liras, R. Dullea, J. Cate
This study identifies how PF-846 selectively stalls ribosome translation by binding in a specific pocket and altering nascent chain path, revealing a mechanism for targeted protein inhibition.
bioRxiv · Jan 9, 2019Biophysics