Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor
O. S. Yousefi, M. Guenther, M. Hoerner, J. Chalupsky, M. Wess, S. M. Brandl, R. W. Smith, C. Fleck, T. Kunkel, M. D. Zurbriggen, T. Hoefer, W. Weber, W. W. A. Schamel
The study shows that the half-life of the ligand-T cell receptor complex determines T cell activation, supporting the kinetic proofreading model.
bioRxiv · Oct 1, 2018Immunology