Author

R. W. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Lewis· 1 shared C. A. Bingman· 1 shared C. A. Zimprich· 1 shared C. Fleck· 1 shared C. R. Corona· 1 shared C. R. M. Asquith· 1 shared D. J. Pagliarini· 1 shared J. Chalupsky· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. Lewis

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Author profile →

2 papers

Recent·Most cited

Small Molecule Modulation of the Archetypal UbiB protein COQ8

N. H. Murray, A. Lewis, C. R. M. Asquith, J. P. R. Pabon, Z. Fang, N. Ptak, R. W. Smith, J. D. Vasta, C. A. Zimprich, C. R. Corona, M. B. Robers, C. A. Bingman, M. L. Gross, K. Henzler-Wildman, D. J. Pagliarini

The paper develops small molecule inhibitors and activators for COQ8A, a UbiB family protein, using crystallography, NMR, and mass spectrometry to modulate its function in CoQ biosynthesis.

bioRxiv · Mar 22, 2022 · PreprintBiochemistry

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

O. S. Yousefi, M. Guenther, M. Hoerner, J. Chalupsky, M. Wess, S. M. Brandl, R. W. Smith, C. Fleck, T. Kunkel, M. D. Zurbriggen, T. Hoefer, W. Weber, W. W. A. Schamel

The study shows that the half-life of the ligand-T cell receptor complex determines T cell activation, supporting the kinetic proofreading model.

bioRxiv · Oct 1, 2018Immunology