PIN1 isomerisation of BRCA1 promotes replication fork protection.
M. R. Daza-Martin, M. Jamshad, K. Starowicz, A. S. Chauhan, J. F. J. Beesley, J. Coles, G. S. Stewart, R. M. Densham, J. R. Morris
This study identifies PIN1-mediated BRCA1 isomerisation as a regulator of replication fork protection through enhanced BRCA1-BARD1-RAD51 interaction, distinct from BRCA1's role in homologous recombination.
bioRxiv · Nov 28, 2018 · PreprintCell Biology