M. Jamshad

Iron is a ligand of SecA-like metal-binding domains in vivo

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

The deSUMOylase SENP2 coordinates homologous recombination and non-homologous end joining by independent mechanisms.

This study identifies SENP2 as a deSUMOylase that differentially regulates homologous recombination and non-homologous end joining through distinct mechanisms, impacting DSB repair and radioresistance.

PIN1 isomerisation of BRCA1 promotes replication fork protection.

This study identifies PIN1-mediated BRCA1 isomerisation as a regulator of replication fork protection through enhanced BRCA1-BARD1-RAD51 interaction, distinct from BRCA1's role in homologous recombination.

Genetic screen suggests an alternative mechanism for azide-mediated inhibition of SecA

The paper uses a genetic screen to show azide inhibits SecA by causing it to backtrack in its ATPase cycle, disrupting membrane and metal cofactor binding.

The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

This study investigates how the C-terminal tail of SecA modulates its activity in cotranslational substrate protein recognition by interacting with ribosomes and substrate proteins.

Evidence for phospholipid export from the gram-negative inner membrane: time to rethink the Mla pathway?

The paper solves the crystal structure of MlaC and shows the Mla pathway exports phospholipids from the inner membrane to the periplasm, challenging the previous belief in retrograde transport.

MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

The paper identifies and characterizes MCE domain proteins in E. coli, showing they localize to the inner membrane and play distinct roles in maintaining outer membrane lipid asymmetry.