The deSUMOylase SENP2 coordinates homologous recombination and non-homologous end joining by independent mechanisms.
A. J. Garvin, A. K. Walker, R. M. Densham, A. S. Chauhan, H. R. Stone, H. L. MacKay, M. Jamshad, K. Starowicz, M. Daza-Martin, J. R. Morris
This study identifies SENP2 as a deSUMOylase that differentially regulates homologous recombination and non-homologous end joining through distinct mechanisms, impacting DSB repair and radioresistance.
Genes & Development · Feb 22, 2019Peer-reviewedCell Biology